【 veterinary medicine name 】 common name: lincomycin hydrochloride injection liquid veterinary medicine prescription
English name: Lincomycin Hydrochloride Injection
Pinyin: Yansuan Linkemeisu Zhusheye
[main ingredients] lincomycin hydrochloride
【 traits 】 this product is colorless or almost colorless transparent liquid.
[pharmacological action] pharmacodynamics Clindamycin belongs to forests amine in antibacterial, antibacterial agent, sensitive bacteria including staphylococcus aureus (including resistance to penicillin strain), streptococcus, pneumococcus, bacillus anthracis, swine erysipelas bacteria, some mycoplasma mycoplasma pneumoniae (pigs, pig nose mycoplasma, joint fluid mycoplasma), leptospira and anaerobic bacteria (flown by bacillus clostridium, tetanus, gas capsule clostridium and most actinomycetes, etc.). The main effect of the bacterial ribosome in the 50S is that the inhibition of protein synthesis by inhibiting the extension of the peptide chain plays an antimicrobial role.
After intramuscular injection, the intramuscular injection was rapid, and the intramuscular injection of 11mg/kg was injected, and the peak concentration was 6.25 g/ml. The binding rate of plasma protein was 57% ~ 72%. In the body, the distribution is widely distributed, and its apparent distribution volume pig is 2.8l/kg. In most tissues, chest water, ascites, and joint fluid can reach an effective level, especially in bone tissue, but not through the blood-brain barrier and into cerebrospinal fluid. The milk can be entered through the placenta and distribution. Mainly in the liver metabolism, through bile and fecal excretion, a small amount of urine excretion.
[drug interactions] 1. There is a synergistic effect on staphylococcus, streptococcus and other gram-positive bacteria when combined with gentamycin.
2. With aminoglycoside and polypeptide antibiotics, may enhance the nerve - muscle joint block effect, and share, erythromycin have antagonism effect, because of the function parts are the same, and the affinity of erythromycin on bacterial ribosomal 50 s subunits than this product.
3. It should not be used to restrain the intestinal peristalsis and the anti-laxative medicine containing white clay.
4. There are no compatibility with kanamycin and neonamycin.
【 indications 】 used for gram positive bacteria infection, especially the resistance to penicillin and stabler sensitive bacterial infections, such as staphylococcus, streptococcus disease, mastitis, also can be used for pig treponema disease and mycoplasma infection of swine asthma.
Intramuscular injection: one dose per 1Kg weight, 0.1ml of pig, 1 time a day; Dog, cat 0.1 ml. Two times a day for 3-5 days.
[adverse reactions] have neuromuscular blocking effects.
Intramuscular injection may cause an overdose of diarrhea or laxation. Although rarely seen, the presence of necessary measures should be taken to prevent dehydration.
Pig 2 days.
[specification] 10ml: 1g
Packaging: 10ml x 10 / box
Storage: sealed.
[approval number] veterinary drug word (2011) 140092615
[executive standard] the 2010 edition of the Chinese animal pharmacopoeia
[license number] (2011) veterinary drug production certificate 14009