[veterinary drug name]
Generic name: nnovacin injection for veterinary drugs
English name: Enro floxacin Injection
Chinese pinyin: ennuoshinto Zhusheye
[main ingredients] nenosha star.
【 traits 】 this product is colorless to pale yellow transparent liquid.
[pharmacological action] a broad-spectrum bactericidal drug of fluoroquinolones for the pharmacodynamics. In e. coli, salmonella, klebsiella bacillus, brucella, pasteurella, pleuropneumonia actinobacillus, erysipelas, bacillus proteus, clayey Mr Charest's bacteria, suppurative corynebacterium, defeated blood pott's bacteria, staphylococcus aureus, mycoplasma, chlamydia, etc all have good effect, on the role of pseudomonas aeruginosa and streptococcus is weak, weak effect on anaerobic bacteria. There are obvious antibacterial effects on sensitive bacteria. The antibacterial mechanism of this product is the DNA rotation enzyme that ACTS on bacterial cells, which interferes with the replication, transcription and repair of bacterial DNA, and the bacteria can't grow and reproduce normally and die.
The intramuscular injection of pharmacokinetics was rapid and complete, and the bioavailability of pigs was 91.9% and the cows were 82%. It is widely distributed in animals, which can be well into tissues and fluid except cerebrospinal fluid. Almost all tissues have higher concentrations of drugs than plasma. The liver metabolism is mainly the ethyl formation ciprofloxacin, which is removed from the 7- piperazine ring, followed by the combination of oxidation and glucuronic acid. Mainly through the kidney (through the renal tubules and glomerular filtration), 15% ~ 50% are discharged from the urine in the original form. The half-life of different species of animals and different drug delivery methods were significantly different. The half-life of the intramuscular injection was 5.9 hours, the horse was 9.9 hours, and the sheep were 1.5 ~ 4.5 hours. Pigs are 4.6 hours.
[drug interactions] 1. This product has synergistic effect with aminoglycoside or broad-spectrum penicillin.
Ca2 +, Mg2 +, Fe3+ and Al3+ plasma can chelate with this product and affect absorption. 3. With the combination of the tea alkali and caffeine, the plasma protein binding rate can be reduced, the concentration of theophylline and caffeine in the blood is abnormal, and even the symptoms of tea alkaline poisoning appear.
4. This product has the effect of inhibiting the liver drug enzyme, which can reduce the clearance rate of the drugs mainly metabolized in the liver, and the blood drug concentration is elevated.
【 indications 】 used for livestock and small animal bacterial disease caused by sensitive bacteria and mycoplasma infection, such as e. coli disease, salmonella disease, pasteurella disease, actinobacillus pleuropneumonia, mastitis, mycoplasma pneumonia, etc.
[usage and dosage] intramuscular injection: at one time, every 1kg of weight, cattle, sheep and pigs 0.05 ml; Dogs, cats, rabbits 0.05 ~ 0.1 ml. 1 ~ 2 times a day, 2 ~ 3 days.
[adverse reactions] 1. Degeneration of the cartilage of young animals affects bone development and causes claudication and pain.
2. The reaction of the digestive system is vomiting, loss of appetite, diarrhea, etc.
3. Skin reactions include erythema, pruritus, urticaria, and photosensitive reactions.
4. Dogs and cats can see allergic reactions, ataxia, seizures.
1. This product is not applicable to horses and dogs before age 8.
Intramuscular injection has a sexual irritant.
3. The central system has the latent excitation function, induced epileptic seizure, the dog with epilepsy is used with caution.
4. Animal and kidney function of animals and animals with careful use, can induce crystallization of urine.
[Hugh's medicine] cattle, sheep 14, pig 10, rabbit 14.
[gage] 10ml:0.5g
[package] 10ml x 10 pieces/box
【 storage 】 shading, seal preservation.